Beilstein J. Org. Chem.2009,5, No. 26, doi:10.3762/bjoc.5.26
catalytic efficacy, flavin derivatives bearing a guanidinium ion as oxoanion binding site were prepared. Chromophore and substrate binding site are linked by a rigid Kemp’sacid structure. The molecular structure of the new flavins was confirmed by an X-ray structure analysis and their photocatalytic
activity was investigated in benzyl ester cleavage, nitroarene reduction and a Diels–Alder reaction. The modified flavins photocatalyze the reactions, but the introduced substrate binding site does not enhance their performance.
Keywords: flavin; guanidine; Kemp’sacid; photocatalysis; template
][25][26][27][28][29][30]. A general drawback of photochemical processes in homogeneous solution is the limited preorganization of the reactants and the chromophore, which may lead to low selectivities and slow conversions in diffusion controlled reactions. To overcome this problem, Kemp’sacid [31
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Graphical Abstract
Scheme 1:
Flavin–guanidinium ion conjugates 1 and 2 and tetraacetyl riboflavin (3).